منابع مشابه
GABA enhances transmission at an excitatory glutamatergic synapse.
GABA mediates both presynaptic and postsynaptic inhibition at many synapses. In contrast, we show that GABA enhances transmission at excitatory synapses between the lateral gastric and medial gastric motor neurons and the gastric mill 6a and 9 (gm6a, gm9) muscles and between the lateral pyloric motor neuron and pyloric 1 (p1) muscles in the stomach of the lobster Homarus americanus. Two-electro...
متن کاملGlycinergic Transmission Shaped by the Corelease of GABA in a Mammalian Auditory Synapse
The firing pattern of neurons is shaped by the convergence of excitation and inhibition, each with finely tuned magnitude and duration. In an auditory brainstem nucleus, glycinergic inhibition features fast decay kinetics, the mechanism of which is unknown. By applying glycine to native or recombinant glycine receptors, we show that response decay times are accelerated by addition of GABA, a we...
متن کاملGABA regulates excitatory synapse formation in the neocortex via NMDA receptor activation.
The development of a balance between excitatory and inhibitory synapses is a critical process in the generation and maturation of functional circuits. Accumulating evidence suggests that neuronal activity plays an important role in achieving such a balance in the developing cortex, but the mechanism that regulates this process is unknown. During development, GABA, the primary inhibitory neurotr...
متن کاملRapid, activity-independent turnover of vesicular transmitter content at a mixed glycine/GABA synapse.
The release of neurotransmitter via the fusion of transmitter-filled, presynaptic vesicles is the primary means by which neurons relay information. However, little is known regarding the molecular mechanisms that supply neurotransmitter destined for vesicle filling, the endogenous transmitter concentrations inside presynaptic nerve terminals, or the dynamics of vesicle refilling after exocytosi...
متن کاملEfficacy and stability of quantal GABA release at a hippocampal interneuron-principal neuron synapse.
We have examined factors that determine the strength and dynamics of GABAergic synapses between interneurons [dentate gyrus basket cells (BCs)] and principal neurons [dentate gyrus granule cells (GCs)] using paired recordings in rat hippocampal slices at 34 degrees C. Unitary IPSCs recorded from BC-GC pairs in high intracellular Cl(-) concentration showed a fast rise and a biexponential decay, ...
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ژورنال
عنوان ژورنال: Journal of Pesticide Science
سال: 1985
ISSN: 1348-589X,1349-0923
DOI: 10.1584/jpestics.10.555